The aim of this work is to obtain new drug delivery systems with prolonged release of biological active folic acid. The prolonged delivery of folic acid, a component of the B complex is essential during the life being responsible with many essential functions including cell division and growth. The obtained materials were characterized by, FTIR and XRD as well as by studying the release profiles of folic acid and water uptake. It can conclude that the release rate is influenced by the used silica precursors.