The working hypothesis on the interaction between the addition biomaterial – peri implant bone is based on the idea that current addition biomaterials based on ceramic and / or collagen form de novo bone interface, are biocompatible and biointegrable. It was evaluated which of the products has the highest clinical success rate and is approaching the gold standard - autogenous bone. Quantitative and qualitative characteristics, determined from histological regeneration of bone, secondary to the application of an autogenous transplantation, namely the addition of different types of biomaterials are reflected by biological reactivity of each implant and systemic reactivity. Results of the osteoscintigrafical investigations necessary for the exposure of the osteogenesis process dynamics are useful when correlated with histological results also with the integration of the implant and new bone formation. The process of "osteostimulation" occurs when an implanted substance influences the osteoreparation, inducing the formation of bone tissue in the periodontal bone defect. So, an experimental study was conducted to test the capacity of some addition biomaterials to induce new bone growth, using the electronic sweeping microscope and EDS spectroscopy as methods to analyze the process of osteointegration.