Tricalcium phosphate has received a special attention as graft for bone regeneration due to its excellent biocompatibility and biodegradability. In this paper, we prepared β-Ca3(PO4)2 granules that were tested in terms of biocompatibility. Firstly, we obtained the ceramic materials by polymeric sponge technique starting from ultrafine powders of β-TCP obtained in our laboratory and polyurethanes sponge from S.C Poliflex. Secondly, the ceramic foam was grained through a sieve with mesh sizes ranging between 500-1000 μm to obtain the grains. The chemical composition and morphology were investigated using X-ray diffraction analysis (XRD) and optical microscopy (OP). The characteristics of the ceramic slurries were determined with the ZetaPlus Brookhaven device. The biocompatibility of the product was analyzed by evaluation of the cytotoxic effects, using the agar diffusion method.