The root canal sealers have the most important role, being responsable for the final sealing of the tooth root. The novelty elements of this study are represented by the endodontic sealing materials developed-the basic monomer, the coloured bioactive glass, hydroxyapatite in combination with the various metal oxide (all obtained in the laboratory), combining the organic monomers or the inorganic powders, as well as the selection of the appropriate ratio between the organic and inorganic phase and of the optimal polymerization system. All the physicochemical properties of the experimental sealers tested are in accordance with ISO 6876:2001 and the literature data.